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Fluid shifts and muscle function in humans during acute simulated weightlessnessThe acute effects of simulated weightlessness on transcapillary fluid balance, tissue fluid shifts, muscle function, and triceps surface reflex time were studied in eight supine human subjects who were placed in a 5 degrees head-down tilt position for 8 hr. Results show a cephalic fluid shift from the legs as indicated by facial edema, nasal congestion, increased urine flow, decreased creatinine excretion, reduced calf girth, and decreased lower leg volume. The interstitial fluid pressure in the tibialis anterior muscle and subcutaneous tissue of the lower leg was found to fall significantly, while other transcapillary pressures (capillary and interstitial fluid colloid osmotic pressures) were relatively unchanged. The total water content of the soleus muscle was unchanged during the head-down tilt. After head-down tilt, isometric strength and isokinetic strength of the plantar flexors were unchanged, while the triceps surae reflex time associated with plantar flexion movement slowed slightly. These results demonstrate a dehydration effect of head-down tilt on muscle and subcutaneous tissue of the lower leg that may affect muscle function.
Document ID
19830049283
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hargens, A. R.
(California Univ. San Diego, CA, United States)
Tipton, C. M.
(California Univ. San Diego, CA, United States)
Gollnick, P. D.
(California Univ. San Diego, CA, United States)
Mubarak, S. J.
(California Univ. San Diego, CA, United States)
Tucker, B. J.
(California Univ. San Diego, CA, United States)
Akeson, W. H.
(U.S. Veterans Administration; California, University San Diego, CA; Iowa, University, Iowa City, IA; Washington State University, Pullman, WA, United States)
Date Acquired
August 11, 2013
Publication Date
April 1, 1983
Publication Information
Publication: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
Volume: 54
ISSN: 0161-7567
Subject Category
Aerospace Medicine
Accession Number
83A30501
Funding Number(s)
CONTRACT_GRANT: NAS9-16039
Distribution Limits
Public
Copyright
Other

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