NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Effect of hindlimb immobilization on the fatigability of skeletal muscleThe effect of 6 weeks of disuse atrophy produced by hindlimb immobilization was studied in situ (33.5 C) in the soleus and extensor digitorum longus muscles of rats. The results indicate that disuse causes preferential alterations in the isometric contractile properties of slow-twitch, as opposed to fast-twitch, skeletal muscles. During continuous contractile activity, atrophied muscles were found to have lower ATP levels and an apparent increase in their dependence on anaerobic metabolism, as reflected by the more extensive depletion of glycogen and enhanced lactate formation. Although the atrophied muscles were determined to have fewer cross bridges and thus generated lower tension, the pattern of decline in active cross-bridge formation and tetanic tension during contractile activity was found to proceed in a manner similar to controls.
Document ID
19830051595
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Witzmann, F. A.
(Marquette Univ. Milwaukee, WI, United States)
Kim, D. H.
(Marquette Univ. Milwaukee, WI, United States)
Fitts, R. H.
(Marquette University Milwaukee, WI, United States)
Date Acquired
August 11, 2013
Publication Date
May 1, 1983
Publication Information
Publication: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
Volume: 54
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
83A32813
Funding Number(s)
CONTRACT_GRANT: NIH-AM-22037
CONTRACT_GRANT: NAS9-15711
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available