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Hyperthermic responses to central injections of some peptide and non-peptide opioids in the guinea-pigThe intracerebroventricular administration of prototype nonpeptide opioid receptor (mu, kappa, and sigma) agonists, morphine, ketocyclazocine, and N-allyl normetazocine and an agonist at both kappa and sigma receptors, pentazocine, was found to induce hyperthermia in guinea pigs. The similar administration of peptide opioids like beta endorphin, methionine endkephalin, leucine endkephaline, and several of their synthetic analogues was also found to cause hyperthermia. Only the liver-like transport system of the three anion transport systems (iodide, hippurate, and liver-like) present in the choroid plexus was determined to be important to the central inactivation of beta-endorphin and two synthetic analogues. Prostaglandins and norepinephrine (NE) as well as cAMP were not involved in peptide and nonpeptide opioid-induced hyperthermia. Naloxone-sensitive receptors were found to be involved in the induction of hyperthermia by morphine and beta-endorphin, while hyperthermic responses to ketocyclazocine, N-allyl normetazocine, pentazocine, Met-enkephalin, Leu-enkephalin, and two of the synthetic analogues were not antagonized by nalozone. The lack of antagonism of naloxone on pyrogen, arachidonic acid, PGE2, dibutyryl cAMP, and NE-induced hyperthermia shows that endogenous opioid peptides are not likely to be central mediators of the hyperthermia induced by these agents.
Document ID
19830055501
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kandasamy, S. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Williams, B. A.
(NASA Ames Research Center Biosystems Div., Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Neuropharmacology
Volume: 22
Issue: 5, 19
ISSN: 0028-3908
Subject Category
Life Sciences (General)
Accession Number
83A36719
Distribution Limits
Public
Copyright
Other

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