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Peptide and non-peptide opioid-induced hyperthermia in rabbitsThe intracerebroventricular administration of prototype nonpeptide opioid receptor (mu, kappa, and sigma) agonists, morphine, ketocyclazocine, and N-allyl-normetazocine was found to induce hyperthermia in rabbits. The similar administration of peptide opioids like beta-endorphin (BE), methionine-enkephalin (ME), and its synthetic analogue D-ala2-methionine-enkephalinamide (DAME) was also found to cause hyperthermia. Results indicate that only the liver-like transport system is important to the ventricular inactivation of BE and DAME. Prostaglandins and norepinephrine were determined not to be involved in peptide and nonpeptide opioid-induced hyperthermia. In addition, cAMP was not required since a phosphodiesterase inhibitor, theophylline, did not accentuate the hyperthermia due to peptide and nonpeptide opioids. Naloxone-sensitive receptors were found to be involved in the induction of hyperthermia by morphine, BE, ME, and DAME since naloxone attenuated them. However, the hyperthermic response to ketocyclazocine and N-allyl-normetazocine was not antagonized by naloxone.
Document ID
19830055767
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kandasamy, S. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Williams, B. A.
(NASA Ames Research Center Biosystems Div., Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Brain Research
Volume: 265
ISSN: 0006-8993
Subject Category
Life Sciences (General)
Accession Number
83A36985
Distribution Limits
Public
Copyright
Other

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