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Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequencesThree 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50-80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.
Document ID
19830057389
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
doi:10.1038/303674a0
Authors
Nordheim, A. (Massachusetts Inst. of Tech. Cambridge, MA, United States)
Rich, A. (MIT Cambridge, MA, United States)
Date Acquired
August 11, 2013
Publication Date
June 23, 1983
Publication Information
Publication: Nature
Volume: 303
ISSN: 0028-0836
Subject Category
Life Sciences (General)
Accession Number
83A38607
Distribution Limits
Public
Copyright
Other

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