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Late skin damage in rabbits and monkeys after exposure to particulate radiationsPreliminary results are reported of experiments on the late effects of exposure to particulate radiations on stem cell populations. Skin biopsies were taken from the ears of rabbits irradiated 2-5 years previously with 530 MeV/amu Ar ions (LET 90 keV/micron), or 365 MeV/amu Ne ions (LET 35 keV micron), and from the chests and inner thighs of rhesus monkeys irradiated 16-18 years previously with 32-MeV protons (LET about 1.2 keV/micron). Skin fibroblast cultures obtained from the biopsy samples in rabbits were observed to undergo dose-dependent decreases in in vitro life span, with estimated survival curves showing the effects of Ar-ion irradiation to be more severe than those of Ne-ion irradiation. In addition, the healing of the biopsy wound was observed to become slower as radiation dose increased. In the monkey, radiation reduced the average number of fibroblasts at the time of cessation of growth in culture. Results thus demonstrate the capacity of skin sampling to reveal stem cell destruction, and have important implications for astronauts and other persons at risk of particle exposure with regard to healing responses to trauma or surgery.
Document ID
19830059631
Document Type
Reprint (Version printed in journal)
Authors
Bergtold, D. S.
(Colorado State Univ. Fort Collins, CO, United States)
Cox, A. B.
(Colorado State Univ. Fort Collins, CO, United States)
Lett, J. T.
(Colorado State University Fort Collins, CO, United States)
Su, C. M.
(Ohio State University Columbus, OH , United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
83A40849
Funding Number(s)
CONTRACT_GRANT: NGR-06-002-128
CONTRACT_GRANT: NAG9-10
CONTRACT_GRANT: NIH-AG-00005
CONTRACT_GRANT: NSG-9045
Distribution Limits
Public
Copyright
Other

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