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Role of metabolic rate and DNA-repair in Drosophila aging Implications for the mitochondrial mutation theory of agingThe notion that injury to mitochondrial DNA is a cause of intrinsic aging was tested by correlating the different respiration rates of several wild strains of Drosophila melanogaster with the life-spans. Respiration rate and aging in a mutant of D. melanogaster deficient in postreplication repair were also investigated. In agreement with the rate of living theory, there was an inverse relation between oxygen consumption and median life-span in flies having normal DNA repair. The mutant showed an abnormally low life-span as compared to the controls and also exhibited significant deficiency in mating fitness and a depressed metabolic rate. Therefore, the short life-span of the mutant may be due to the congenital condition rather than to accelerated aging.
Document ID
19830060643
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Miquel, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Binnard, R.
(NASA Ames Research Center Moffett Field, CA, United States)
Fleming, J. E.
(Linus Pauling Institute of Science and Medicine Palo Alto, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Experimental Gerontology
Volume: 18
ISSN: 0531-5565
Subject Category
Life Sciences (General)
Accession Number
83A41861
Distribution Limits
Public
Copyright
Other

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