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A unified mathematical theory of electrophoretic processesA mathematical theory is presented which shows that each of the four classical electrophoretic modes (zone electrophoresis, moving boundary electrophoresis, isotachophoresis, and isoelectric focusing) is based on the same general principles and can collectively be described in terms of a single set of equations. This model can predict the evolution of the four electrophoretic modes as a function of time. The model system is one-dimensional, neglecting the effects of electroosmosis, temperature gradients, and any bulk flows of liquid. The model is based on equations which express the components' dissociation equilibria, the mass transport due to electromigration and diffusion, electroneutrality, and the conservation of mass and charge. The model consists of a system of coupled partial differential and nonlinear algebraic equations which can be solved numerically by use of a computer. The versatility of this model was verified using an example of a three-component system containing cacodylate, tris hydroxylmethylaminomethane, and histidine. Results show that this model not only correctly predicts the characteristic features of each electrophoretic mode, but also gives details of the concentration, pH, and conductivity profiles not easily amenable to direct experimental measurement.
Document ID
19830064541
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Bier, M.
(Arizona Univ. Tucson, AZ, United States)
Palusinski, O. A.
(Arizona Univ. Tucson, AZ, United States)
Mosher, R. A.
(Arizona Univ. Tucson, AZ, United States)
Graham, A.
(Arizona, University Tucson, AZ, United States)
Saville, D. A.
(Princeton University Princeton, NJ, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Subject Category
Inorganic And Physical Chemistry
Meeting Information
Meeting: Electrophoresis ''82; Fourth International Conference
Location: Athens
Country: Greece
Start Date: April 21, 1982
End Date: April 24, 1982
Accession Number
83A45759
Funding Number(s)
CONTRACT_GRANT: NAS8-32950
CONTRACT_GRANT: NSG-7333
CONTRACT_GRANT: NSF CPE-81-03079
Distribution Limits
Public
Copyright
Other

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