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Growth and differentiation of mammalian embryonic tissues exposed to hypergravity in vivo and in vitroIn about 10 years or so, men and women from Earth will be long-term inhabitants of a space station aboard which plants and animals will be growing and developing in gravities other than that of Earth. The effect of gravitational changes on development was examined. It is indicated that differentiation is speeded up under excess G and slowed in low or null G. The effects of exposure to excess gravity on fusion of the embryonic mouse secondary palate were studied. During fusion, the palatal shelves first adhere by means of glycoproteins appearing along the medial epithelial edge (MEE). The contacting epithelia then reorganize and undergo programmed cell death, allowing the underlying mesenchymes to come in contact. The process of cell death occurs in vitro at about the same rate that it occurs in vivo.
Document ID
19840010801
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Duke, P. J.
(Texas Univ. Health Science Center Houston, TX, United States)
Date Acquired
August 12, 2013
Publication Date
February 1, 1984
Publication Information
Publication: NASA. Washington NASA Space Biol. Program
Subject Category
Life Sciences (General)
Accession Number
84N18869
Funding Number(s)
CONTRACT_GRANT: NAGW-438
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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