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Record Details

Record 58 of 5030
Transdermal scopolamine in the prevention of motion sickness - Evaluation of the time course of efficacy
Author and Affiliation:
Homick, J. L.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Reschke, M. F.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Degioanni, J.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Cintron-Trevino, N. M.(NASA Johnson Space Center, Houston, TX, United States)
Kohl, R. L.(Technology, Inc., Houston, TX, United States)
Abstract: This study evaluated the time course of efficacy of transdermal scopolamine in the prevention of motion sickness induced by exposure to coriolis stimulation in a rotating chair. We measured levels of efficacy, quantified side effects and symptoms, and determined inter- and intra-subject variability following use of transdermal scopolamine. The response to transdermal scopolamine was highly variable, although overall we recorded a 40 percent improvement in test scores 16-72 h after application of the transdermal system. This variability could not be explained solely by the levels of scopolamine present in the blood. The improvement was not due to the artifactual repression by scopolamine of selected symptoms of motion sickness. An unexpectedly high incidence of side effects was reported. It was concluded that the therapeutic use of transdermal scopolamine be evaluated individually and that individuals be cautioned that subsequent usage may not always be effective.
Publication Date: Nov 01, 1983
Document ID:
19840029274
(Acquired Nov 28, 1995)
Accession Number: 84A12061
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Aviation, Space, and Environmental Medicine; p. 994-1000; (ISSN 0095-0562); 54
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: NASA Johnson Space Center; Houston, TX, United States
Technology, Inc.; Houston, TX, United States
Description: 7p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AEROSPACE MEDICINE; HYOSCINE; MOTION SICKNESS; EVALUATION; EXPERIMENT DESIGN; VARIABILITY
Imprint And Other Notes: Aviation, Space, and Environmental Medicine (ISSN 0095-0562), vol. 54, Nov. 1983, p. 994-1000.
Availability Source: Other Sources
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