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Metabolic alkalosis during immobilization in monkeys (M. nemestrina)The systemic and renal acid-base response of monkeys during ten weeks of immobilization was studied. By three weeks of immobilization, arterial pH and bicarbonate concentrations were elevated (chronic metabolic alkalosis). Net urinary acid excretion increased in immobilized animals. Urinary bicarbonate excretion decreased during the first three weeks of immobilization, and then returned to control levels. Sustained increases in urinary ammonium excretion were seen throughout the time duration of immobilization. Neither potassium depletion nor hypokalemia was observed. Most parameters returned promptly to the normal range during the first week of recovery. Factors tentatively associated with changes in acid-base status of monkeys include contraction of extracellular fluid volume, retention of bicarbonate, increased acid excretion, and possible participation of extrarenal buffers.
Document ID
Document Type
Reprint (Version printed in journal)
Young, D. R.
(NASA Ames Research Center Biomedical Reserch Div., Moffett Field, CA, United States)
Yeh, I.
(NASA Ames Research Center Moffett Field, CA, United States)
Swenson, R. S.
(U.S. Veterans Administration Medical Center Palo Alto, CA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Calcified Tissue International
Volume: 35
ISSN: 0008-0594
Subject Category
Life Sciences (General)
Distribution Limits
No Preview Available