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Record Details

Record 3 of 63
Metabolic alkalosis during immobilization in monkeys (M. nemestrina)
Author and Affiliation:
Young, D. R.(NASA Ames Research Center, Biomedical Reserch Div., Moffett Field, CA, United States)
Yeh, I.(NASA Ames Research Center, Moffett Field, CA, United States)
Swenson, R. S.(U.S. Veterans Administration Medical Center, Palo Alto, CA, United States)
Abstract: The systemic and renal acid-base response of monkeys during ten weeks of immobilization was studied. By three weeks of immobilization, arterial pH and bicarbonate concentrations were elevated (chronic metabolic alkalosis). Net urinary acid excretion increased in immobilized animals. Urinary bicarbonate excretion decreased during the first three weeks of immobilization, and then returned to control levels. Sustained increases in urinary ammonium excretion were seen throughout the time duration of immobilization. Neither potassium depletion nor hypokalemia was observed. Most parameters returned promptly to the normal range during the first week of recovery. Factors tentatively associated with changes in acid-base status of monkeys include contraction of extracellular fluid volume, retention of bicarbonate, increased acid excretion, and possible participation of extrarenal buffers.
Publication Date: Jan 01, 1983
Document ID:
19840037734
(Acquired Nov 28, 1995)
Accession Number: 84A20521
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Calcified Tissue International (ISSN 0008-0594); 35; 472-476
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: NASA Ames Research Center; Moffett Field, CA, United States
Veterans Administration Hospital; Palo Alto, CA, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ALKALOSIS; IMMOBILIZATION; METABOLISM; PHYSIOLOGICAL EFFECTS; STRESS (PHYSIOLOGY); ACID BASE EQUILIBRIUM; ELECTROLYTE METABOLISM; HYPOKINESIA; MONKEYS; PHYSIOCHEMISTRY; URINALYSIS
Imprint And Other Notes: Calcified Tissue International (ISSN 0008-0594), vol. 35, 1983, p. 472-476.
Availability Source: Other Sources
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