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The spatial distribution of fixed mutations within genes coding for proteinsAn examination has been conducted of the extensive amino acid sequence data now available for five protein families - the alpha crystallin A chain, myoglobin, alpha and beta hemoglobin, and the cytochromes c - with the goal of estimating the true spatial distribution of base substitutions within genes that code for proteins. In every case the commonly used Poisson density failed to even approximate the experimental pattern of base substitution. For the 87 species of beta hemoglobin examined, for example, the probability that the observed results were from a Poisson process was the minuscule 10 to the -44th. Analogous results were obtained for the other functional families. All the data were reasonably, but not perfectly, described by the negative binomial density. In particular, most of the data were described by one of the very simple limiting forms of this density, the geometric density. The implications of this for evolutionary inference are discussed. It is evident that most estimates of total base substitutions between genes are badly in need of revision.
Document ID
19840039013
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Holmquist, R.
(California Univ. Berkeley, CA, United States)
Goodman, M.
(California, University Berkeley, CA, United States)
Conroy, T.
(California Univ. Berkeley, CA, United States)
Czelusniak, J.
(Wayne State University Detroit, MI, United States)
Date Acquired
August 12, 2013
Publication Date
November 1, 1983
Publication Information
Publication: Journal of Molecular Evolution
Volume: 19
ISSN: 0022-2844
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NGR-05-003-460
CONTRACT_GRANT: NSF PCM-76-08627
CONTRACT_GRANT: NSF DEB-78-10717
Distribution Limits
Public
Copyright
Other
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