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Prevention of metabolic alterations caused by suspension hypokinesia in leg muscles of ratsRats were subjected to tail-cast suspension hypokinesia for 6 days with one leg immobilized in dorsal flexion by casting. Control animals were also tail-casted. The soleus, gastrocnemius and plantaris muscles of uncasted hypokinetic legs were smaller than control muscles. Dorsal flexion prevented atrophy of these muscles and caused the soleus to hypertrophy. The anterior muscles were unaffected by hypokinesia. The smaller size of the soleus of the uncasted leg relative to the dorsal flexed and weight bearing limbs correlated with slower protein synthesis and faster proteolysis. The capacity of this muscle to synthesize glutamine (gln), which carries nitrogenous waste from muscle was also measured. Although tissue homogenates showed higher activities of gln synthetase, the rate of de novo synthesis was not altered in intact muscle but the tissue ratio of gln/glutamate was decreased. Glutamate and ATP were not limiting for gln synthesis, but availability of ammonia may be a limiting factor for this process in hypokinesia.
Document ID
19840041572
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Tischler, M. E.
(Arizona Univ. Tucson, AZ, United States)
Jaspers, S. R.
(Arizona Univ. Tucson, AZ, United States)
Fagan, J. M.
(Arizona, University Tucson, AZ, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1983
Publication Information
Publication: Physiologist, Supplement
Volume: 26
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
84A24359
Funding Number(s)
CONTRACT_GRANT: NAGW-227
Distribution Limits
Public
Copyright
Other

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