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Fine-structural changes in the midgut of old Drosophila melanogasterSenescent fine-structural changes in the midgut of Drosophila melanogaster are investigated. A large number of midgut mitochondria in old flies exhibit nodular cristae and a tubular system located perpendicular to the normal cristae orientation. Anterior intestinal cells show a senescent accumulation of age pigment, either with a surrounding two-unit membrane or without any membrane. The predominant localization of enlarged mitochondria and pigment in the luminal gut region may be related to the polarized metabolism of the intestinal cells. Findings concur with previous observations of dense-body accumulations and support the theory that mitochondria are involved in the aging of fixed post-mitotic cells. Demonstrated by statistical analyses is that mitochondrial size increase is related to mitochondrial variation increase.
Document ID
Document Type
Reprint (Version printed in journal)
Anton-Erxleben, F.
(Hamburg, Universitaet Hamburg, Germany)
Miquel, J.
(Hamburg Univ. Germany)
Philpott, D. E.
(NASA Ames Research Center Life Science Dept., Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Mechanisms of Ageing and Development
Volume: 23
ISSN: 0047-6374
Subject Category
Life Sciences (General)
Accession Number
Distribution Limits

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