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A suspension model for hypokinetic/hypodynamic and antiorthostatic responses in the mouseHypokinetic/hypodynamic and antiorthostatic responses to weightlessness and bedrest were simulated in mice using a suspension technique. Animals were suspended for 1 or 2 weeks in an antiorthostatic posture and positioned to permit freedom of movement but eliminate load bearing by the hindlimbs. Suspended mice exhibited reduced food and water intakes and a rapid 10 percent decrease in body weight to a level which was maintained for the remainder of the suspension period. Diuresis was evident in suspended mice, but the natriuresis and kaliuresis previously observed in the suspended rat were not evident. Differential hindlimb muscle atrophy and increased excretion of urea and ammonia were also noted in suspended mice. Postsuspension recovery studies indicated that the recovery process was highly effective. These results document specific responses in the mouse and similarities in the responses of mice and rats to suspension. These studies expand the utility of the suspension model and suggest that the mouse may be useful in future studies simulating both weightlessness and bedrest.
Document ID
19840057568
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Steffen, J. M.
(Louisville Univ. KY, United States)
Dombrowski, M. J.
(Louisville Univ. KY, United States)
Musacchia, X. J.
(Louisville Univ. KY, United States)
Sonnenfeld, G.
(Louisville, University Louisville, KY, United States)
Mandel, A. D.
(NASA Ames Research Center Moffett Field, CA, United States)
Robb, R.
(Louisville Univ. KY, United States)
Date Acquired
August 12, 2013
Publication Date
July 1, 1984
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 55
ISSN: 0095-0562
Subject Category
Life Sciences (General)
Accession Number
84A40355
Funding Number(s)
CONTRACT_GRANT: NSG-2325
CONTRACT_GRANT: NCC2-213
Distribution Limits
Public
Copyright
Other

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