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Enkephalin inhibition of angiotensin-stimulated release of oxytocin and vasopressinThe effect of intracerebroventricular (ICV) pretreatment with 100 ng/5 microliter leucine(5)-enkephalin (LE) on the increase in plasma oxytocin (OT) and vasopressin (VP) caused by ICV injection of 10, 50, or 100 ng/5 microliter of angiotensin II (AII) is investigated experimentally in conscious adult male Sprague-Dawley rats; the effects of water-deprivation dehydration and lactation/suckling (in female rats) are also studied. An OT radioimmunoassay (RIA) with a sensitivity of 800 fg/ml (described in detail) and the VP RIA technique of Keil and Severs (1977) are employed. Administration of AII or dehydration for 48 or 72 h cause a significant increase in OT and VP without affecting the ratio, while lactation and suckling increase OT only. LE pretreatment inhibits significantly but does not suppress the AII-stimulated OT-VP response.
Document ID
19840058208
Document Type
Reprint (Version printed in journal)
Authors
Keil, L. C. (NASA Ames Research Center Moffett Field, CA, United States)
Chee, O. (NASA Ames Research Center Biomedical Research Div., Moffett Field, CA, United States)
Rosella-Dampman, L. M. (NASA Ames Research Center Moffett Field, CA, United States)
Emmert, S. (NASA Ames Research Center Moffett Field, CA, United States)
Summy-Long, J. Y. (Pennsylvania State University Hershey, PA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1984
Publication Information
Publication: Brain Research
Issue: 297
ISSN: 0006-8993
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NIH-HL-26039
CONTRACT_GRANT: NIH-HL-25726
Distribution Limits
Public
Copyright
Other