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Establishing homologies in protein sequencesComputer-based statistical techniques used to determine homologies between proteins occurring in different species are reviewed. The technique is based on comparison of two protein sequences, either by relating all segments of a given length in one sequence to all segments of the second or by finding the best alignment of the two sequences. Approaches discussed include selection using printed tabulations, identification of very similar sequences, and computer searches of a database. The use of the SEARCH, RELATE, and ALIGN programs (Dayhoff, 1979) is explained; sample data are presented in graphs, diagrams, and tables and the construction of scoring matrices is considered.
Document ID
19840058254
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Dayhoff, M. O.
Barker, W. C.
Hunt, L. T.
Date Acquired
August 12, 2013
Publication Date
January 1, 1983
Subject Category
Life Sciences (General)
Accession Number
84A41041
Funding Number(s)
CONTRACT_GRANT: NIH-GM-08710
CONTRACT_GRANT: NASW-3317
Distribution Limits
Public
Copyright
Other

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