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Record 4 of 30
Beta-interferon inhibits cell infection by Trypanosoma cruzi
Author and Affiliation:
Kierszenbaum, F.(Michigan State University, East Lansing, MI, United States)
Sonnenfeld, G.(Louisville, University, Louisville, KY, United States)
Abstract: Beta interferon has been shown to inhibit the capacity of bloodstream forms of the flagellate Trypanosoma cruzi, the causative agent of Chagas' disease, to associate with and infect mouse peritoneal macrophages and rat heart myoblasts. The inhibitory effect was abrogated in the presence of specific antibodies to the interferon. Pretreatment of the parasites with interferon reduced their infectivity for untreated host cells, whereas pretreament of either type of host cell did not affect the interaction. The effect of interferon on the trypanosomes was reversible; the extent of the inhibitory effect was significantly reduced afer 20 min, and was undetectable after 60 min when macrophages were used as host cells. For the myoblasts, 60 min elapsed before the inhibitory effect began to subside and 120 min elapsed before it became insignificant or undetectable.
Publication Date: Feb 01, 1984
Document ID:
19840062762
(Acquired Nov 28, 1995)
Accession Number: 84A45549
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Journal of Immunology (ISSN 0022-1767); 132; 905-908
Publisher Information: United States
Contract/Grant/Task Num: NIH-AI-14848; NIH-AI-17041; NCC2-213
Financial Sponsor: NASA; United States
Organization Source: Michigan State Univ.; East Lansing, MI, United States
Louisville Univ.; KY, United States
Description: 4p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: IMMUNOASSAY; INTERFERON; MACROPHAGES; PARASITIC DISEASES; PHYSIOLOGICAL DEFENSES; TRYPANOSOME; ANTIBODIES; CELLS (BIOLOGY); INFECTIOUS DISEASES; INHIBITORS
Imprint And Other Notes: Journal of Immunology (ISSN 0022-1767), vol. 132, Feb. 1984, p. 905-908.
Availability Source: Other Sources
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