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Role of Glucocorticoids in the Response to Unloading of Muscle Protein and Amino Acid MetabolismIntact control (weight bearing) and suspended rats gained weight at a similar rate during a 6 day period. Adrenaectomized (adx) weight bearing rats gained less weight during this period while adrenalectomized suspended rats showed no significant weight gain. Cortisol treatment of both of these groups of animals caused a loss of body weight. Results from these studies show several important findings: (1) Metabolic changes in the extensor digitorum longus muscle of suspended rats are due primarily to increased circulating gluccorticoids; (2) Metabolic changes in the soleus due to higher steroid levels are probably potentiated by greater numbers of receptors; and (3) Not all metabolic responses in the unloaded soleus muscle are due to direct action of elevated glucocorticoids or increased sensitivity to these hormones.
Document ID
19850017766
Document Type
Conference Paper
Authors
Tischler, M. E. (Arizona Univ. Tucson, AZ, United States)
Jaspers, S. R. (Arizona Univ. Tucson, AZ, United States)
Date Acquired
August 12, 2013
Publication Date
April 1, 1985
Publication Information
Publication: NASA. Washington NASA Space Biol. Program:
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NAGW-227
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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