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Disuse Induced Changes in the Cholinergic System of Sciatic Nerve and Slow and Fast Twitch Muscle of RatsHindlimb suspension was used as a model of disuse in experiments studing the effects of reduced muscle activity on AChE and its molecular forms, choline acetyltransferase and nicotinic receptor binding in innervated slow and fast muscle. The weight of SOL was reduced to 64% within one week and continued to decrease progressively up to the third week when the weight was reduced to 40% as compared to controls. EDL showed a significant decrease in its weight only at the end of three weeks hypokinesia when it was reduced to 71% of control. Biochemical and histochemical findings are summarized. From these data and from morphological findings it is evident that some properties of skeletal muscles are strongly dependent on patterns and level of loadbearing and on motor unit activiy. With suspension-induced disuse, the usually slow SOL appeared to change its characteristics such as fiber type distribution and AChE activity to one that more resembled a faster muscle. It is important to note that hypokinesia induced changes either physiological, biochemical or morphological, are totally reversible as the induced changes returned to control levels within a week after cessation of disuse.
Document ID
19850017770
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Dettbarn, W. D.
(Vanderbilt Univ. Nashville, TN, United States)
Gupta, R. C.
(Vanderbilt Univ. Nashville, TN, United States)
Misulis, K. E.
(Vanderbilt Univ. Nashville, TN, United States)
Date Acquired
August 12, 2013
Publication Date
April 1, 1985
Publication Information
Publication: NASA. Washington NASA Space Biol. Program:
Subject Category
Life Sciences (General)
Accession Number
85N26081
Funding Number(s)
CONTRACT_GRANT: NAG2-301
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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