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The unresponsiveness of the immune system of the rat to hypergravityThe immune response in rats exposed to simulated hypergravity (2.1 G and 3.1 G) by chronic centrifugation was assessed. Rats were immunized with sheep red blood cells (SRBC), either on the day of initial exposure to hypergravity (hyper-G), or after being centrifuged for 28 d and remaining on the centrifuge thereafter. Pair-fed and ad libitum fed noncentrifuged controls were used. Although there were some alterations in leukocyte counts, hyper-G did not systematically affect the primary or secondary anti-SRBC response, hematocrits, or the sizes of the liver, spleen, kidneys, thymus, or adrenal glands. The immune system is thus remarkably homeostatic under hypergravity conditions which do affect other physiologic parameters.
Document ID
Document Type
Reprint (Version printed in journal)
Scibetta, S. M.
(NASA Ames Research Center Moffett Field, CA, United States)
Caren, L. D.
(NASA Ames Research Center Moffett Field, CA, United States)
Oyama, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field; Santa Clara, University, Santa Clara, CA, United States)
Date Acquired
August 12, 2013
Publication Date
November 1, 1984
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 55
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
Distribution Limits

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