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Radial maze performance in three strains of mice - Role of the fimbria/fornixThree strains of mice were tested on an 8-arm radial maze, an index of hippocampus-dependent spatial memory. Levels of performance differed betweens strains with C57Br/cdj greater than Balb/cj greater than C57B1/6j. Lesions of the fimbria/fornix disrupted performance in the C57Br and Balb strains: the C57Bl mice never performed better than chance before or after surgery. Choline acetyltransferase activity in hippocampus was not correlated with radial maze performance. These findings suggest a possible genetic contribution towards radial maze behavior.
Document ID
19850039821
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Reinstein, D. K.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Deboissiere, T.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Robinson, N.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Wurtman, R. J.
(MIT Cambridge, MA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Brain Research
Volume: 263
ISSN: 0006-8993
Subject Category
Life Sciences (General)
Accession Number
85A21972
Funding Number(s)
CONTRACT_GRANT: NIH-MH-28783
CONTRACT_GRANT: NGR-22-009-627
Distribution Limits
Public
Copyright
Other

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