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Evolutionary constraints and the neutral theoryThe neutral theory of molecular evolution postulates that nucleotide substitutions inherently take place in DNA as a result of point mutations followed by random genetic drift. In the absence of selective constraints, the substitution rate reaches the maximum value set by the mutation rate. The rate in globin pseudogenes is about 5 x 10 to the -9th substitutions per site per year in mammals. Rates slower than this indicate the presence of constraints imposed by negative (natural) selection, which rejects and discards deleterious mutations.
Document ID
19850041719
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Jukes, T. H. (California, University Berkeley, CA, United States)
Kimura, M. (National Institute of Genetics Misima, Shizuoka, Japan)
Date Acquired
August 12, 2013
Publication Date
January 1, 1984
Publication Information
Publication: Journal of Molecular Evolution
Volume: 21
Issue: 1 19
ISSN: 0022-2844
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NGR-05-003-460
Distribution Limits
Public
Copyright
Other