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Hyper-G stress-induced hyperglycemia in rats mediated by glucoregulatory hormonesThe present investigation is concerned with possible relations of the hyperglycemic response of rats exposed to hyper-G stress to (1) alterations in blood levels of the glucoregulatory hormones and gluconeogenic substrates, and (2) changes in insulin response on muscle glucose uptake. Male Sprague-Dawley rats weighing 250-300 g were used in the study. The results of the experiments indicate that the initial rapid rise in blood glucose of rats exposed to hyper-G stress is mediated by increases in circulating catecholamines and glucagon, both potent stimulators of hepatic gluconeogenesis. Lactate, derived from epinephrine stimulation of muscle glycogenolysis, appears to be a major precursor for the initial rise in blood glucose. The inhibition of the insulin-stimulated glucose uptake by muscle tissues may be a factor in the observed sustained hyperglycemia.
Document ID
19850045515
Document Type
Reprint (Version printed in journal)
Authors
Daligcon, B. C. (NASA Ames Research Center Moffett Field, CA, United States)
Oyama, J. (NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1985
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 56
ISSN: 0095-6562
Subject Category
LIFE SCIENCES (GENERAL)
Distribution Limits
Public
Copyright
Other