NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Androgen-estrogen synergy in rat levator ani muscle Glucose-6-phosphate dehydrogenaseThe effects of castration and hormone administration on the activity of glucose-6-phosphate dehydrogenase in the rat levator ani muscle were studied. Castration caused a decrease in enzyme activity and in wet weight of the levator ani muscle. Chronic administration of testosterone propionate increased glucose-6-phosphate dehydrogenase activity in the levator ani muscle of castrated rats; the magnitude of the recovery of enzyme activity was related to the length of time of exposure to testosterone propionate after castration as well as to the length of time the animals were castrated. The longer the period of castration before exposure to testosterone propionate, the greater the effect. This result may be related to previously reported castration-mediated increases in androgen receptor binding in muscle. Dihydrotestosterone was less effective than testosterone propionate in enhancing glucose-6-phosphate dehydrogenase activity in the levator ani muscle from castrated rats; estradiol-17-beta alone was ineffective. Combined treatment with estradiol-17-beta and dihydrotestosterone, however, was as effective as testosterone alone. Thus, androgens and estrogens may exert synergistic effects on levator ani muscle.
Document ID
19850045875
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Max, S. R.
(Maryland, University Baltimore, MD, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1984
Publication Information
Publication: Molecular and Cellular Endocrinology
Volume: 38
ISSN: 0303-7207
Subject Category
Life Sciences (General)
Accession Number
85A28026
Funding Number(s)
CONTRACT_GRANT: NAG2-100
CONTRACT_GRANT: NIH-NS-15760
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available