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Effects of deceleration on the humoral antibody response in ratsEffects of hypergravity, simulated by chronic centrifugation, followed by a return to normal G (deceleration) on the immune system of rats were investigated. Two groups of male rats (28 days at 2.1 G, and 3.1 G) were compared to the control group (1.0 G). The animals were immunized by i.p. injections of sheep red blood cells on days 29, 42, and 57, and bled on days 36, 47, and 62. While the centrifuged rats ate and gainedsignificantly less than the control rats, the antibody titers and the organ/body mass ratios for the adrenal glands, kidneys, lungs, heart, and thymus were unaffected by gravity exposures, as were the values of the hematocrit and the white blood cell counts. It is concluded that deceleration does not adversely affect these particular aspects of the immune system.
Document ID
19850062469
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Barone, R. P.
(Santa Clara Univ. CA, United States)
Caren, L. D.
(Santa Clara, University CA, United States)
Oyama, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
July 1, 1985
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 56
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
85A44620
Distribution Limits
Public
Copyright
Other

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