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Effects of chronic centrifugation on micePrevious studies have shown that exposure to excess gravity in vitro alters the developmental sequence in embryonic mouse limbs and palates (Duke, Janer and Campbell, 1984; Duke, 1983). The effects of excess gravity on in vivo mammalian development was investigated using a small animal centrifuge. Four-week old female mice exposed to excess gravities of 1.8-3.5 G for eight weeks weighed significantly less than controls. Mice were mated after five weeks of adaptation to excess G, and sacrificed either at gestational day 12 or 18. There were fewer pregnancies in the centrifuged group (4/36) than in controls (9/31), and crown rump lengths (CRL) of embryos developing in the centrifuge were less than CRLs of 1-G embryos. These results show that although immersed in amniotic fluid, embryos are responsive to Delta-G.
Document ID
19850065055
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Janer, L.
(Texas Univ. Houston, TX, United States)
Duke, J.
(Texas, University Houston, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1984
Publication Information
Publication: Physiologist, Supplement
Volume: 27
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
85A47206
Funding Number(s)
CONTRACT_GRANT: NAGW-438
Distribution Limits
Public
Copyright
Other

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