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Purification and Cultivation of Human Pituitary Growth Hormones Secreting CellsThe rat and human pituitary gland contains a mixture of hormone producing cell types. The separation of cells which make growth hormone (GH) is attempted for the purpose of understanding how the hormone molecule is made within the pituitary cell; what form(s) it takes within the cell; and what form(s) GH assumes as it leaves the cell. Since GH has a number of biological targets (e.g., muscle, liver, bone), the assessment of the activities of the intracellular/extracellular GH by new and sensitive bioassays. GH cells contained in the mixture was separated by free flow electrophoresis. These experiments show that GH cells have different electrophoretic mobilities. This is relevant to NASA since a lack of GH could be a prime causative factor in muscle atrophy. Further, GH has recently been implicated in the etiology of motion sickness in space. Continous flow electrophoresis experiment on STS-8 showed that GH cells could be partially separated in microgravity. However, definitive cell culture studies could not be done due to insufficient cell recoveries.
Document ID
19860000673
Acquisition Source
Legacy CDMS
Document Type
Other
Authors
Hymer, W. C.
(Pennsylvania State Univ. University Park, United States)
Todd, P.
(Pennsylvania State Univ. University Park, United States)
Grindeland, R.
(Pennsylvania State Univ. University Park, United States)
Lanham, W.
(Pennsylvania State Univ. University Park, United States)
Morrison, D.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Date Acquired
August 12, 2013
Publication Date
May 1, 1985
Publication Information
Publication: NASA, Washington Microgravity Sci. and Appl. Program Tasks
Subject Category
Astronautics (General)
Accession Number
86N10140
Funding Number(s)
CONTRACT_GRANT: NAS9-15566
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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