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Record 12 of 357
Evolution of thiol protective systems in prokaryotes
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Author and Affiliation:
Fahey, R. C.(California Univ., San Diego, La Jolla, CA, United States)
Newton, G. L.(California Univ., San Diego, La Jolla, CA, United States)
Abstract: Biological thiols are essential elements in most aspects of cell function but undergo rapid oxidation to disulfides in the presence of oxygen. The evolution of systems to protect against such oxygen toxicity was essential to the emergence of aerobic life. The protection system used by eukaryotes is based upon glutathione (GSH) and GSH-dependent enzymes but many bacteria lack GSH and apparently use other mechanisms. The objective of this research is to elaborate the thiol protective mechanisms employed by prokaryotes of widely divergent evolutionary origin and to understand why GSH became the central thiol employed in essentially all higher organisms. Thiol-selective fluorescent labeling and HPLC analysis has been used to determine key monothiol components.
Publication Date: May 01, 1986
Document ID:
19860017424
(Acquired Nov 04, 1995)
Accession Number: 86N26896
Subject Category: SPACE BIOLOGY
Document Type: Conference Paper
Publication Information: NASA, Washington Second Symposium on Chemical Evolution and the Origin and Evolution of Life; p 96
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: California Univ., San Diego; La Jolla, CA, United States
Description: 1p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: AEROBES; BACTERIA; BIOLOGICAL EVOLUTION; GLUTATHIONE; OXIDATION; PROKARYOTES; THIOLS; BIOCHEMISTRY; ENZYMES; EUKARYOTES; PROTECTION
Imprint And Other Notes: In NASA, Washington Second Symposium on Chemical Evolution and the Origin and Evolution of Life p 96 (SEE N86-26844 17-55)
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