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Increased gluconeogenesis in rats exposed to hyper-G stressThe effect of glucogenesis on the plasma glucose and liver glycogen of rats exposed to hyper-G stress is investigated. Twelve male Sprague-Dawley rats are injected with C-14 lactate, alanine, of glycerol, and six of the rats are exposed to 3.1 G for 0.25, 0.50, and 1.0 hr. The plasma glucose and liver glycogen of the centrifuged and noncentrifuged rats are analyzed. A significant increase in the C-14 incorporation of the substrate into the plasma glucose and liver glycogen is observed in the centrifuged rats. The injection of 5-methoxyindole-2-carboxylic acid, a gluconeogenesis inhibitor, results in a blocked increase in plasma glucose and liver glycogen. The role of epinephrine on the hyperglycemic and liver glycogen responses of centrifuged rats is studied. It is concluded that the initial increase in plasma glucose and liver glycogen in rats exposed to hyper-G stress is the result of an increased rate of gluconeogenesis.
Document ID
19860033659
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Daligcon, B. C.
(NASA Ames Research Center Moffett Field, CA, United States)
Oyama, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Hannak, K.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1985
Publication Information
Publication: Life Sciences
Volume: 37
Issue: 3, 19
ISSN: 0024-3205
Subject Category
Life Sciences (General)
Accession Number
86A18397
Distribution Limits
Public
Copyright
Other

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