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Endocrine correlates of susceptibility to motion sicknessMotion sickness releases ACTH, epinerphrine, and norepinephrine. The endocrine responses to motion sickness, adaptive responses leading to the resolution of the syndrome, and the way in which antimotion-sickness drugs influence the endocrine responses were studied. Susceptible or insusceptible subjects were administered antimotion-sickness drugs prior to stressful stimulation. Insusceptible subjects displayed more pronounced elevations of ACTH, epinephrine, and norepinephrine after stressful motion. Predrug levels of ACTH were higher in insusceptible subjects (p less than 0.01). Acute blockade of hormone responses to stressful motion or alteration of levels of ACTH by drugs were not correlated with individual susceptibility. No correlation was apparent between epinephrine and ACTH release. These endocrine differences may represent neurochemical markers for susceptibility to motion, stress, or general adaptability, and it may be that the chronic modulation of their levels might be more effective in preventing motion sickness than the acute blockage or stimulation of specific receptors.
Document ID
19860034096
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kohl, R. L.
(NASA Johnson Space Center; Universities Space Research Association, Houston, TX, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 56
ISSN: 0095-6562
Subject Category
Aerospace Medicine
Accession Number
86A18834
Distribution Limits
Public
Copyright
Other

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