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Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspensionPrevious work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly, the rise in soleus tyrosine following unloading reflects the more negative protein balance. Other major changes we found included slower synthesis of glutamine as indicated by lower ratios of glutamine/glutamate and reduced levels of aspartate which coincide with slower aspartate and ammonia metabolism in vitro. In conjunction with the study of SL-3 rats, which were subjected to 12 h of post-flight gravity, a study of the effects of 12 h eight bearing on metabolism of 6-day unloaded hindlimb muscles was carried out.
Document ID
19860045688
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Tischler, M. E.
(Arizona Univ. Tucson, AZ, United States)
Henriksen, E. J.
(Arizona Univ. Tucson, AZ, United States)
Jacob, S.
(Arizona Univ. Tucson, AZ, United States)
Cook, P.
(Arizona Univ. Tucson, AZ, United States)
Jaspers, S.
(Arizona, University Tucson, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30426
Funding Number(s)
CONTRACT_GRANT: NAGW-227
Distribution Limits
Public
Copyright
Other

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