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Changes in muscle protein composition induced by disuse atrophy - Analysis by two-dimensional electrophoresisUsing 320 g rats, a two-dimensional electrophoretic analysis of muscle proteins in the soleus and EDL muscles from hindlimbs maintained load-free for 10 days is performed. Statistical analysis of the two-dimensional patterns of control and suspended groups reveals more protein alteration in the soleus muscle, with 25 protein differences, than the EDL muscle, with 9 protein differences, as a result of atrophy. Most of the soleus differences reside in minor components. It is suggested that the EDL may also show alteration in its two-dimensional protein map, even though no significant atrophy occurred in muscle wet weight. It is cautioned that strict interpretation of data must take into account possible endocrine perturbations.
Document ID
19860045702
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ellis, S.
(NASA Ames Research Center Moffett Field, CA, United States)
Giometti, C. S.
(Argonne National Laboratory IL, United States)
Riley, D. A.
(Wisconsin Medical College, Milwaukee, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30440
Distribution Limits
Public
Copyright
Other

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