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Effects of weightlessness on neurotransmitter receptors in selected brain areasThe central nervous system receptor dynamics of rats exposed to 7 days of microgravity are studied. The receptor affinity and receptor number at the hippocampus, lateral frontal cortex, prefrontal cortex, corpus striatum, cerebellum and pons-medulla, and the Na(+)/K(+)ATPase activity are examined. The data reveal that there is no significant change in the receptor affinity and receptor number for the lateral frontal cortex, prefrontal cortex, cerebellum and pons-medulla; however, there is an increase from 81 + or - 11 to 120 + or 5 fmole/mg protein in the receptor number for hippocampal binding, and a decrease in receptor number for the striatum from 172 + or - 14 to 143 + or - 10 fmoles/mg protein. A 9 percent decrease in Mg-dependent Na(+)/K(+)ATPase activity is observed. It is detected that the terminal mechanism may be affected by exposure to microgravity.
Document ID
19860045724
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Miller, J. D.
(California Univ. Davis, CA, United States)
Murakami, D. M.
(California, University Davis, United States)
Mcmillen, B. A.
(California Univ. Davis, CA, United States)
Mcconnaughey, M. M.
(California Univ. Davis, CA, United States)
Williams, H. L.
(East Carolina University Greenville, NC, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30462
Funding Number(s)
CONTRACT_GRANT: NAS2-10536
Distribution Limits
Public
Copyright
Other

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