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Microgravity changes in heart structure and cyclic-AMP metabolismThe effects of microgravity on cardiac ultrastructure and cyclic AMP metabolism in tissues of rats flown on Spacelab 3 are reported. Light and electron microscope studies of cell structure, measurements of low and high Km phosphodiesterase activity, cyclic AMP-dependent protein kinase activity, and regulatory subunit compartmentation show significant deviations in flight animals when compared to ground controls. The results indicate that some changes have occurred in cellular responses associated with catecholamine receptor interactions and intracellular signal processing.
Document ID
19860045727
Document Type
Reprint (Version printed in journal)
Authors
Philpott, D. E. (NASA Ames Research Center Moffett Field, CA, United States)
Fine, A. (NASA Ames Research Center Moffett Field, CA, United States)
Kato, K. (NASA Ames Research Center Moffett Field, CA, United States)
Egnor, R. (NASA Ames Research Center Moffett Field, CA, United States)
Cheng, L. (NASA Ames Research Center Moffett Field, CA; USVA, Medical Center, New York, NY; NIH, National Institute of Dental Research, B, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
LIFE SCIENCES (GENERAL)
Distribution Limits
Public
Copyright
Other