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Effect of flight in mission SL-3 on interferon-gamma production by ratsRats flown in Space Shuttle mission SL-3 were sacrificed after flight and spleens were removed. Cultures of spleen cells were challenged with the mitogen concanavalin-A to attempt to induce interferon-gamma. Most control, ground-based rats had spleen cells that produced moderate titers of interferon-gamma. Spleen cells from flown rats did not produce interferon-gamma in most cases, and one flown rat produced minimally detectable amounts of interferon. These data suggest that interferon-gamma production was inhibited in rats flown in mission SL-3 immediately upon return to earth.
Document ID
19860045729
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gould, C. L.
(NASA Ames Research Center Moffett Field, CA, United States)
Williams, J. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Mandel, A. D.
(NASA Ames Research Center Moffett Field, CA, United States)
Sonnenfeld, G.
(NASA Ames Research Center Moffett Field, CA; Louisville, University, KY, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30467
Funding Number(s)
CONTRACT_GRANT: NCC2-213
Distribution Limits
Public
Copyright
Other

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