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Record Details

Record 35 of 279
Morphologic and histochemical studies of bone cells from SL-3 rats
Author and Affiliation:
Doty, S. B.(Columbia University, New York, United States)
Abstract: Previous studies of rat bone following space flight indicate a significant reduction in new bone formation as a result of hypogravity. In the present study of animals from SL-3 flight, the cellular activity of the bone forming cells, the osteoblasts, was investigated. Measurements of alkaline and acid phosphatase, Golgi activity, secretory granule size, and lysosomal activity, all indicated very little difference between flight and flight-simulated controls. However, there was a tendency for osteoblasts in compact bone of flight animals to show a smaller cytoplasmic volume compared to non-flight controls. If, as in previous studies, a significant reduction in bone formation occurred, it could be due to a normal level of procollagen degradation within these smaller osteoblasts, resulting in less collagen secretion per cell.
Publication Date: Dec 01, 1985
Document ID:
19860045735
(Acquired Nov 28, 1995)
Accession Number: 86A30473
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Physiologist, Supplement (ISSN 0031-9376); 28; S-225
Publisher Information: United States
Contract/Grant/Task Num: NCC2-325
Financial Sponsor: NASA; United States
Organization Source: Columbia Univ.; New York, NY, United States
Description: 2p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BONES; CELLS (BIOLOGY); GRAVITATIONAL PHYSIOLOGY; HISTOCHEMICAL ANALYSIS; WEIGHTLESSNESS; COLLAGENS; CYTOPLASM; MORPHOLOGY; RATS; SPACE FLIGHT; SPACELAB PAYLOADS; TIBIA
Imprint And Other Notes: (International Union of Physiological Sciences, Commission on Gravitational Physiology, Annual Meeting, 7th, Niagara Falls, NY, Oct. 13-18, 1985) Physiologist, Supplement (ISSN 0031-9376), vol. 28, Dec. 1985, p. S-225, S-226.
Miscellaneous Notes: S-226
Availability Source: Other Sources
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