NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon
 

Record Details

Record 10 of 48
Role of carbonic anhydrase in bone resorption induced by 1,25 dihydroxyvitamin D3 in vitro
Author and Affiliation:
Hall, G. E.(Texas Technological Univ., Lubbock, TX, United States)
Kenny, A. D.(Texas Tech University, Health Science Center, Lubbock, United States)
Abstract: The calvaria of 5-to-6-day-old mice treated with 1 x 10 to the -8th M of 1,25(OH)2D3 in vitro for 48 hours are examined in order to study the function of carbonic anhydrase in bone resorption. Calcium concentrations in the culture were measured to assess bone resorption. It is observed that 1,25(OH)2D3 effectively stimulates bone resorption in vitro and the resorption is dose-dependent. The effects of azetazolamide on 1,25(OH)2D3-induced bone resorption are investigated. The data reveal that 1,25(OH)2D3-induced calcium release is associated with an increase in the carbonic anhydrase activity of bone, and bone alkaline phosphatase activity is decreased and acid phosphatase activity is increased in response to 1,25(OH)2D3. A two-fold mechanism for 1,25(OH)2D3-induced bone resorption is proposed; the first mechanism is an indirect activation of osteoclasts and the second involves an interaction between hormone and osteoclast precursors.
Publication Date: Jan 01, 1985
Document ID:
19860058711
(Acquired Nov 28, 1995)
Accession Number: 86A43449
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Calcified Tissue International (ISSN 0008-0594); 37; 134-142
Publisher Information: United States
Contract/Grant/Task Num: NIH-AM-19475; NSG-2137
Financial Sponsor: NASA; United States
Organization Source: Texas Technological Univ.; Lubbock, TX, United States
Description: 9p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BONE MINERAL CONTENT; CALCIFEROL; CALCIUM METABOLISM; CARBONIC ANHYDRASE; ENZYME ACTIVITY; CULTURE TECHNIQUES; PHYSIOCHEMISTRY
Imprint And Other Notes: Calcified Tissue International (ISSN 0008-0594), vol. 37, 1985, p. 134-142.
Availability Source: Other Sources
› Back to Top
Find Similar Records
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: August 18, 2011
Contact Us