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Protein crystal growth in spaceThe advantages of protein crystallization in space, and the applications of protein crystallography to drug design, protein engineering, and the design of synthetic vaccines are examined. The steps involved in using protein crystallography to determine the three-dimensional structure of a protein are discussed. The growth chamber design and the hand-held apparatus developed for protein crystal growth by vapor diffusion techniques (hanging-drop method) are described; the experimental data from the four Shuttle missions are utilized to develop hardware for protein crystal growth in space and to evaluate the effects of gravity on protein crystal growth.
Document ID
19870035328
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Bugg, C. E.
(Alabama, University Birmingham, United States)
Clifford, D. W.
(McDonnell Douglas Astronautics Co. Saint Louis, MO, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1987
Subject Category
Materials Processing
Report/Patent Number
AIAA PAPER 87-0387
Accession Number
87A22602
Funding Number(s)
CONTRACT_GRANT: NAS8-36611
CONTRACT_GRANT: NAGW-813
Distribution Limits
Public
Copyright
Other

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