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Protein turnover in adipose tissue from fasted or diabetic ratsProtein synthesis and degradation in vitro were compared in epididymal fat pads from animals deprived of food for 48 h or treated 6 or 12 days prior with streptozotocin to induce diabetes. Although both fasting and diabetes led to depressed (-24 to -57 percent) protein synthesis, the diminution in protein degradation (-63 to -72 percent) was even greater, so that net in vitro protein balance improved dramatically. Insulin failed to inhibit protein degradation in fat pads of these rats as it does for fed animals. Although insulin stimulated protein synthesis in fat pads of fasted and 12 day diabetic rats, the absolute change was much smaller than that seen in the fed state. The inhibition of protein degradation by leucine also seems to be less in fasted animals, probably because leucine catabolism is slower in fasting. These results show that fasting and diabetes may improve protein balance in adipose tissue but diminish the regulatory effects of insulin.
Document ID
19870036165
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Tischler, Marc E.
(Arizona Univ. Tucson, AZ, United States)
Ost, Alan H.
(Arizona Univ. Tucson, AZ, United States)
Coffman, Julia
(Arizona, University Tucson, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1986
Publication Information
Publication: Life Sciences
Volume: 39
Issue: 16 1
ISSN: 0024-3205
Subject Category
Life Sciences (General)
Accession Number
87A23439
Funding Number(s)
CONTRACT_GRANT: NIH-AM-28647
CONTRACT_GRANT: NAGW-227
Distribution Limits
Public
Copyright
Other

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