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Record Details

Record 19 of 2780
Kinetics of the hydrolysis of guanosine 5'-phospho-2-methylimidazolide
External Online Source: doi:10.1007/BF01809815
Author and Affiliation:
Kanavarioti, Anastassia(NASA Ames Research Center, Moffett Field, CA, United States)
Abstract: The hydrolysis kinetics of guanosine 5'-phospho-2-methylimidazolide (2-MeImpG) in aqueous buffered solutions of various pH's was studied at 75 and 37 C, using spectrophotometric and HPLC techniques. The hydrolysis was found to be very slow even at low pH. At 75 C and pH at or below l.0, two kinetic processes were observed: the more rapid one was attributed to the hydrolysis of the phosphoimidazolide P-N bond; the second, much slower one, was attributed to the cleavage of the glycosidic bond. It is noted that the P-N hydrolysis in phosphoimidazolides is very slow compared to other phosphoramidates, and that this might be one of the reasons why the phosphoimidazolides showed an extraordinary ability to form long oligomers under template-directed conditions.
Publication Date: Jan 01, 1986
Document ID:
19870038544
(Acquired Nov 28, 1995)
Accession Number: 87A25818
Subject Category: SPACE BIOLOGY
Document Type: Journal Article
Publication Information: Origins of Life (ISSN 0302-1688); 17; 85-103
Publisher Information: Netherlands
Financial Sponsor: NASA; United States
Organization Source: NASA Ames Research Center; Moffett Field, CA, United States
Description: 19p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BIOLOGICAL EVOLUTION; CHEMICAL EVOLUTION; GUANOSINES; HYDROLYSIS; REACTION KINETICS; CHEMICAL BONDS; IMIDES; METHYL COMPOUNDS; SPECTROPHOTOMETRY
Imprint And Other Notes: Origins of Life (ISSN 0302-1688), vol. 17, 1986, p. 85-103. Research supported by the National Research Council and NASA.
Miscellaneous Notes: Research supported by the National Research Council and NASA
Availability Source: Other Sources
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