NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Hyperbaric hyperoxia reversibly inhibits erythrocyte phospholipid fatty acid turnoverThe effect of hyperbaric hyperoxia on the acylation of membrane phospholipid was studied by measuring the rates of activation of exogenous tritiated oleic acid to acyl thioester and of transesterification of the thioester into membrane phospholipids in intact human erythrocytes obtained 1 h after an exposure of the subjects to a hyperbaric oxygen atmosphere (3.5 h, 100 pct O2, 3 ATA). Exposure to pure oxygen was found to inhibit both the acylation and transesterification reactions by more than 30 percent, with partial recovery detected 24 h later. On the other hand, no rate changes were observed when isolated membranes from the same batches of cells were used in similar experiments. It is suggested that the decrease in the incorporation of tritiated oleic acid after hyperbaric hyperoxia may reflect an early event in the pathogenesis of oxygen-induced cellular injury and that it may be a useful index for the assessment of the tolerance of tissues to hyperoxia.
Document ID
19870046667
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dise, Craig A.
(Pennsylvania Univ. Philadelphia, PA, United States)
Clark, James M.
(Pennsylvania Univ. Philadelphia, PA, United States)
Lambersten, Christian J.
(Pennsylvania Univ. Philadelphia, PA, United States)
Goodman, David B. P.
(Pennsylvania, University Philadelphia, United States)
Date Acquired
August 13, 2013
Publication Date
February 1, 1987
Publication Information
Publication: Journal of Applied Physiology
Volume: 62
ISSN: 0161-7567
Subject Category
Aerospace Medicine
Accession Number
87A33941
Funding Number(s)
CONTRACT_GRANT: NAS9-17238-1C
CONTRACT_GRANT: N00014-81-C-0826-P04
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available