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Glucocorticoid receptor-mediated induction of glutamine synthetase in skeletal muscle cells in vitroThe regulation by glucocorticoids of glutamine synthetase in L6 muscle cells in culture is studied. Glutamine synthetase activity was strikingly enhanced by dexamethasone. The dexamethasone-mediated induction of glutamine synthetase activity was blocked by RU38486, a glucocorticoid antagonist, indicating the involvement of intracellular glucocorticoid receptors in the induction process. RU38486 alone was without effect. Northern blot analysis revealed that dexamethasone-mediated enhancement of glutamine synthetase activity involves increased levels of glutamine synthetase mRNA. Glucocorticoids regulate the expression of glutamine synthetase mRNA in cultured muscle cells via interaction with intracellular receptors. Such regulation may be relevant to control of glutamine production by muscle.
Document ID
19870053671
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Max, Stephen R.
(Maryland Univ. Baltimore, MD, United States)
Thomas, John W.
(Maryland Univ. Baltimore, MD, United States)
Banner, Carl
(Maryland Univ. Baltimore, MD, United States)
Vitkovic, Ljubisa
(Maryland Univ. Baltimore, MD, United States)
Konagaya, Masaaki
(Maryland, University Baltimore; NIH, National Institute of Neurological and Communicative Diseases, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1987
Publication Information
Publication: Endocrinology
Volume: 120
Issue: 4 19
ISSN: 0013-7227
Subject Category
Life Sciences (General)
Accession Number
87A40945
Funding Number(s)
CONTRACT_GRANT: NIH-HD-16596
CONTRACT_GRANT: NAG2-100
Distribution Limits
Public
Copyright
Other

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