NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon

Record Details

Record 5 of 91
Glucocorticoid receptor-mediated induction of glutamine synthetase in skeletal muscle cells in vitro
Author and Affiliation:
Max, Stephen R.(Maryland Univ., Baltimore, MD, United States)
Thomas, John W.(Maryland Univ., Baltimore, MD, United States)
Banner, Carl(Maryland Univ., Baltimore, MD, United States)
Vitkovic, Ljubisa(Maryland Univ., Baltimore, MD, United States)
Konagaya, Masaaki(Maryland, University, Baltimore)
et al.
Abstract: The regulation by glucocorticoids of glutamine synthetase in L6 muscle cells in culture is studied. Glutamine synthetase activity was strikingly enhanced by dexamethasone. The dexamethasone-mediated induction of glutamine synthetase activity was blocked by RU38486, a glucocorticoid antagonist, indicating the involvement of intracellular glucocorticoid receptors in the induction process. RU38486 alone was without effect. Northern blot analysis revealed that dexamethasone-mediated enhancement of glutamine synthetase activity involves increased levels of glutamine synthetase mRNA. Glucocorticoids regulate the expression of glutamine synthetase mRNA in cultured muscle cells via interaction with intracellular receptors. Such regulation may be relevant to control of glutamine production by muscle.
Publication Date: Jan 01, 1987
Document ID:
(Acquired Nov 28, 1995)
Accession Number: 87A40945
Document Type: Journal Article
Publication Information: Endocrinology (ISSN 0013-7227); 120; 4, 19
Publisher Information: United States
Contract/Grant/Task Num: NIH-HD-16596; NAG2-100
Financial Sponsor: NASA; United States
Organization Source: Maryland Univ.; Baltimore, MD, United States
National Inst. of Neurological Diseases and Stroke; Bethesda, MD, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
Imprint And Other Notes: Endocrinology (ISSN 0013-7227), vol. 120, no. 4, 1987, p. 1-5.
Availability Source: Other Sources
› Back to Top
Find Similar Records
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: August 18, 2011
Contact Us