Bone and muscle - The structural system in long duration space missions

Losses of bone mineral and muscle mass have been observed, and in varying degrees measured, following all long duration missions in space. These observations portend an unacceptable threat to the crews' ability to return to earth, without protracted rehabilitation, following periods of a year or more in microgravity. The impact to crew capabilities and productivity in space is not well understood. Past research has dealt with bone loss and muscle atrophy as two separate problems with little discernible relationship. This paper reviews the available information on both and suggests a combined structural approach for future research.