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Size and metabolic properties of fibers in rat fast-twitch muscles after hindlimb suspensionThe effect of hind-limb suspension (HS) on single fibers of the medial gastrocnemius (MG) and the tibialis anterior (TA) muscles were studied in rats. Fiber area and the activities of succinate dehydrogenase (SDH) and alpha-glycerophosphate dehydrogenase (GPD) were determined in tissue sections using an image analysis system. After 28 days of HS, the MG atrophied 28 percent, whereas the TA weight was maintained. Both dark- and light-ATPase fibers in the deep region of the MG had decreased cross-sectional areas following HS, with the atrophic response being twice as great in the light-ATPase fibers than in the dark-ATPase fibers. Following HS, mean SDH activities of both fiber types were significantly lower in the MG and TA than in the CON; by contrast, mean GPD activities were either maintained at the CON level or were higher in both MG and TA muscles. The data suggest an independence of the mechanisms determining the muscle fiber size and the metabolic adaptations associated with HS.
Document ID
19870059300
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Roy, Roland R.
(California Univ. Los Angeles, CA, United States)
Bello, Maureen A.
(California Univ. Los Angeles, CA, United States)
Bouissou, Phillip
(California Univ. Los Angeles, CA, United States)
Edgerton, V. Reggie
(California, University Los Angeles, United States)
Date Acquired
August 13, 2013
Publication Date
June 1, 1987
Publication Information
Publication: Journal of Applied Physiology
Volume: 62
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
87A46574
Funding Number(s)
CONTRACT_GRANT: NCA2-IR-390-502
Distribution Limits
Public
Copyright
Other

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