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Early and late mammalian responses to heavy charged particlesThis overview summarizes murine results on acute lethality responses, inactivation of marrow CFU-S and intestinal microcolonies, testes weight loss, life span shortening, and posterior lens opacification in mice irradiated with heavy charged particles. RBE-LET relationships for these mammalian responses are compared with results from in vitro studies. The trend is that the maximum RBE for in vivo responses tends to be lower and occurs at a lower LET than for inactivation of V79 and T-1 cells in culture. Based on inactivation cross sections, the response of CFU-S in vivo conforms to expectations from earlier studies with prokaryotic systems and mammalian cells in culture. Effects of heavy ions are compared with fission spectrum neutrons, and the results are consistent with the interpretation that RBEs are lower than for fission neutrons at about the same LET, probably due to differences in track structure.
Document ID
19870061740
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ainsworth, E. J.
(California, University Berkeley, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1986
Publication Information
Publication: Advances in Space Research
Volume: 6
Issue: 11 1
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
87A49014
Funding Number(s)
CONTRACT_GRANT: DE-AC03-76SF-00098
CONTRACT_GRANT: NASA ORDER T-71630-B
CONTRACT_GRANT: NIH-CA-15184
Distribution Limits
Public
Copyright
Other

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