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Morphometric studies of heavy ion damage in the brains of rodentsThe relative biological effectiveness (RBE) of different heavy ions for the mammalian brain was determined in mice irradiated at 100 days of age with He-4, C-12, Ne-20, Fe-56, Ar-40, or Co-60 gamma photons (with the primary particle LET values ranging from 2 to 650). Brain preparations were examined 16 months later for volume changes in the external plexiform layer (P-zone) of the olfactory bulb and an internal region (G-zone), which consists of the granule cells, the internal plexiform layer, and the mitral cell layer. The result indicate that the volume changes did occur in the olfactory bulb, not only in absolute terms but also when expressed as the ratio of the structures to each other and to the bulb as a whole. While the observed increased neuronal loss in mice receiving 700 cGy of Co-60 support the earlier data from irradiated rabbits, the increases observed in bulbar volumes and in the volume ratios of the P and the G zones measured in the mice given lower doses (320 or 160 cGy of He or C), were not expected.
Document ID
19870061751
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kraft, L. M.
(NASA Ames Research Center Moffett Field, CA, United States)
Cox, A. B.
(Colorado State University Fort Collins, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1986
Publication Information
Publication: Advances in Space Research
Volume: 6
Issue: 11 1
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
87A49025
Funding Number(s)
CONTRACT_GRANT: NCC2-227
Distribution Limits
Public
Copyright
Other

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