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Use of diphosphonates to correct disorders in calcium metabolism and mineral composition of bone tissue with 60-day hypokinesia in ratsCompounds of the diphosphonate group suppress bone resorption and bone tissue metabolism, from which it was assumed that they can be used for the prevention of osteoporosis and disorders of calcium homeostasis in humans during space flight. Two compounds of this group were used for preventive purposes in 60 day hypokinesia in rats. The results showed that diphosphonates have a marked effect on calcium metabolism and the condition of the bone tissues under conditions of long term hypokinesia: they reduce the content of ionized calcium in blood, delay the loss of calcium and phosphorus by the bone tissue, and to a considerable degree prevent reduction of bone density. This confirms the possibility of using compounds of this group for correcting and preventing changes of bone tissue and mineral metabolism during long term hypokinesia.
Document ID
19880011423
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Morukov, B. V.
(NASA Headquarters Washington, DC United States)
Zaychik, V. YE.
(NASA Headquarters Washington, DC United States)
Ivanov, V. M.
(NASA Headquarters Washington, DC United States)
Orlov, O. I.
(NASA Headquarters Washington, DC United States)
Date Acquired
September 5, 2013
Publication Date
March 1, 1988
Subject Category
Life Sciences (General)
Report/Patent Number
NAS 1.77:20220
NASA-TT-20220
Accession Number
88N20807
Funding Number(s)
CONTRACT_GRANT: NASW-4307
Distribution Limits
Public
Copyright
Public Use Permitted.
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